From Miami Airport:
Go West on East-West Expressway (836) to Florida Turnpike - 7.5 miles.
Go Southwest on Florida's Turnpike (Toll) to US 1 (end of Florida Turnpike) - 17.5 miles.
Continue on US 1 to Key West - 131.6 miles.
Once you reach Key West at the top of the island, stay to the right & continue on US 1.
Total distance: 167.9 miles 3 1/2 hours
From Fort Lauderdale Airport:
**(Do not take I 95 south toward Miami! This is the main commute corridor between Ft. Lauderdale and Miami and can add significant time.
Leaving the Ft Lauderdale airport follow signs to I 595. Drive west on I 595
Take the exit on the left onto I-75 South toward Miami
Take exit 5 for Florida's Turnpike South toward Key West Toll road
Merge onto Florida 821 Toll South/Homestead Extension of Florida's Turnpike
Exit on the left onto US 1 S/NE 1st Ave toward Key West, continue on US 1 to Key West
Total distance: 178.25 miles 4 hours